Dynamics of airway response in lung microsections: a tool for studying airway-extra cellular matrix interactions
نویسندگان
چکیده
منابع مشابه
Studying human airway pharmacology in microsections: application of videomicrometry.
The influence of endogenously-released mediators and activated eosinophils on the airway lumen and the effect of passive sensitization on anti-immunoglobulin (Ig)-E-induced contractile responses was investigated by videomicrometry. Human bronchial sections of 2-3 mm internal diameter, placed in 250 microL Hank's balanced salt solution on microtitre plates, were monitored and recorded by digitiz...
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BACKGROUND We previously observed that allergen-exposed mice exhibit remodeling of large bronchial-associated blood vessels. The aim of the study was to examine whether vascular remodeling occurs also in vessels where a spill-over effect of bronchial remodeling molecules is less likely. METHODS We used an established mouse model of allergic airway inflammation, where an allergic airway inflam...
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Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix metalloproteinase-1 (MMP-1) is present in remodelled airways but its relationship with ECM proteins and the resulting functional consequences are unknown. We used airway smooth muscle cells (ASM) and bronchial biopsies...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2016
ISSN: 1423-0127
DOI: 10.1186/s12929-016-0263-2